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Sunday, 7 October 2012

Polytar AF

1. Name Of The Medicinal Product

Polytar AF

2. Qualitative And Quantitative Composition

Tar Blend 1% w/w, Zinc Pyrithione 1% w/w in a shampoo base

Tar Blend comprises:

Pine tar, Cade oil, Coal Tar Solution, Arachis Oil extract of Coal Tar.

3. Pharmaceutical Form

Medicated Shampoo

4. Clinical Particulars

4.1 Therapeutic Indications

Polytar AF is indicated in the topical treatment of scalp disorders such as dandruff, seborrhoeic dermatitis and psoriasis.

4.2 Posology And Method Of Administration

Shake the bottle before use. Wet the hair and massage Polytar AF into the hair, scalp and surrounding skin. Leave for 2-3 minutes, then rinse thoroughly.

Polytar AF should be used two or three times weekly for at least 3 weeks or until the condition clears.

4.3 Contraindications

Polytar AF should not be used by patients with known hypersensitivity to any of the ingredients.

4.4 Special Warnings And Precautions For Use

Avoid contact with the eyes. Tar products may cause skin irritation, rashes and, rarely, photosensitivity. Zinc pyrithione may cause dermatitis, should this occur, Polytar AF should be discontinued.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None known.

4.6 Pregnancy And Lactation

The safety of Polytar AF in human pregnancy and lactation has not been established.

4.7 Effects On Ability To Drive And Use Machines

None.

4.8 Undesirable Effects

None.

4.9 Overdose

Not applicable.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Tar blend:

Tars suppress DNA synthesis in hyperplastic skin, this inhibits mitotic activity and protein synthesis. By decreasing proliferation and dermal infiltration, they promote a return to normal keratinisation. Tars also have vasoconstricting astringent and antipruritic properties.

Zinc Pyrithione:

Zinc Pyrithione has antibacterial and antifungal properties. It is fungicidal against the pathogenic yeasts of the pityrosporum genus which are implicated in dandruff and seborrhoeic dermatitis.

5.2 Pharmacokinetic Properties

Not Applicable.

5.3 Preclinical Safety Data

Not Applicable.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Coconut diethanolamide

Triethanolamine Lauryl Sulphate

Carbomer

Sodium Hydroxide

Hypromellose

Octoxinol

Glycerol

Imidurea

Purified Water

6.2 Incompatibilities

None

6.3 Shelf Life

24 months

6.4 Special Precautions For Storage

Store below 25^oC

6.5 Nature And Contents Of Container

High density polyethylene bottles of 25ml, 65ml, 150ml, 250ml, 350ml, 400ml, 1000ml

6.6 Special Precautions For Disposal And Other Handling

There are no special instructions for use or handling of Polytar AF.

7. Marketing Authorisation Holder

GlaxoSmithKline UK Limited

980 Great West Road

Brentford

Middlesex

TW8 9GS

Trading as Stiefel

Stockley Park West

Uxbridge

Middlesex

UB11 1BT

8. Marketing Authorisation Number(S)

PL 19494/0061

9. Date Of First Authorisation/Renewal Of The Authorisation

16^th March 1992.

10. Date Of Revision Of The Text

20 December 2010

Saturday, 6 October 2012

Neevo DHA

Pronunciation: pree-NATE-al muhl-tee-VYE-ta-min/VYE-ta-min A/MIN-er-als/EYE-urn/el-METH-il-FOE-late/FOE-lik AS-id
Generic Name: Prenatal Multivitamin without Vitamin A with Minerals, Iron, L-methylfolate, Folic Acid, and DHA
Brand Name: Examples include Prenate DHA and Neevo DHA

Accidental overdose of products that contain iron is a leading cause of fatal poisoning in children younger than 6 years old. Keep this and all medicines out of the reach of children. In case of accidental ingestion, call the poison control center or doctor at once.

Neevo DHA is used for:

Treating or preventing a lack of vitamins or minerals before, during, and after pregnancy and while breast-feeding. It may also be used for other conditions as determined by your doctor.

Neevo DHA is a vitamin, mineral, iron, folic acid, and docosahexaenoic acid (DHA) combination. It works by providing vitamins and minerals to the body to help meet nutritional requirements.

Do NOT use Neevo DHA if:

you are allergic to any ingredient in Neevo DHA

you have hemochromatosis (a disorder of iron metabolism) or high levels of iron in your blood

you are taking an anticoagulant (eg, warfarin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Neevo DHA:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances, including soy, fish, or fish oil

if you have stomach or intestinal problems (eg, colitis, Crohn disease, diverticulitis), pernicious anemia or other blood problems (eg, anemia, porphyria), bleeding problems (eg, hemophilia), peptic ulcer, or kidney stones

if you have had multiple blood transfusions

Some MEDICINES MAY INTERACT with Neevo DHA. Tell your health care provider if you are taking any other medicines, especially any of the following:

Oral anticoagulants (eg, warfarin) because the risk of bleeding may be increased by Neevo DHA

Fluorouracil because the risk of its side effects may be increased by Neevo DHA

Doxycycline, hydantoins (eg, phenytoin), levodopa, penicillamine, or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by Neevo DHA

This may not be a complete list of all interactions that may occur. Ask your health care provider if Neevo DHA may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Neevo DHA:

Use Neevo DHA as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Neevo DHA by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Take Neevo DHA by mouth with a full glass of water (8 oz/240 mL).

Do not take an antacid within 1 hour before or 2 hours after you take Neevo DHA.

Avoid taking Neevo DHA with dairy products; they may interfere with the absorption of the iron in Neevo DHA.

Many medicines (eg, used for infection, blood pressure, low blood platelet levels, osteoporosis, thyroid problems) should not be taken at the same time as Neevo DHA; their effectiveness may be decreased. Ask your doctor or pharmacist if your dose of Neevo DHA should be separated from your dose of any of your other medicines.

If you miss a dose of Neevo DHA, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Neevo DHA.

Important safety information:

Do not exceed the recommended dose or take Neevo DHA for longer than prescribed without checking with your doctor.

Do not take large doses of vitamins while you use Neevo DHA unless your doctor tells you to.

Neevo DHA has pyridoxine (vitamin B₆) in it. Before you start any new medicine, check the label to see if it has pyridoxine (vitamin B₆) in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Some brands of Neevo DHA may contain fish oil or soy. If you have had an allergic reaction to fish, fish oil, or soy, ask your pharmacist if your brand contains fish oil or soy.

Neevo DHA may darken the stools. This is normal and not a cause for concern.

Neevo DHA has iron in it. Iron overdose is a leading cause of fatal poisoning in children younger than 6 years old. In case of an overdose, call a doctor or poison control center right away.

Neevo DHA may interfere with certain lab tests, including tests used to check for blood in the stool. Be sure your doctor and lab personnel know you are taking Neevo DHA.

PREGNANCY and BREAST-FEEDING: Neevo DHA is intended for use during pregnancy and breast-feeding. If you are or will be breast-feeding while you use Neevo DHA, check with your doctor.

Possible side effects of Neevo DHA:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dark or discolored stools; diarrhea; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood or streaks of blood in the stools; stomach pain or cramping.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Neevo DHA side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include black, tarry stools; chest pain; loss of balance; seizure; severe nausea, vomiting, diarrhea, or stomach pain; shortness of breath; sluggishness; trouble breathing; unusual tiredness or weakness; unusually pale skin; weak pulse.

Proper storage of Neevo DHA:

Store Neevo DHA at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Neevo DHA out of the reach of children and away from pets.

General information:

If you have any questions about Neevo DHA, please talk with your doctor, pharmacist, or other health care provider.

Neevo DHA is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Neevo DHA. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Neevo DHA resources

Neevo DHA Side Effects (in more detail)
Neevo DHA Use in Pregnancy & Breastfeeding
Drug Images
Neevo DHA Drug Interactions
1 Review for Neevo DHA - Add your own review/rating

Neevo DHA Concise Consumer Information (Cerner Multum)

CitraNatal Assure Prescribing Information (FDA)

CitraNatal Harmony Prescribing Information (FDA)

Concept DHA Prescribing Information (FDA)

Docosavit Prescribing Information (FDA)

Folcal DHA Prescribing Information (FDA)

Folcaps Care One Prescribing Information (FDA)

Gesticare DHA Prescribing Information (FDA)

Inatal Advance Prescribing Information (FDA)

Inatal Ultra Prescribing Information (FDA)

Multi-Nate DHA Prescribing Information (FDA)

Multi-Nate DHA Extra Prescribing Information (FDA)

Multifol Plus Concise Consumer Information (Cerner Multum)

Natelle One Prescribing Information (FDA)

Paire OB Plus DHA Prescribing Information (FDA)

PreNexa Prescribing Information (FDA)

PreferaOB Prescribing Information (FDA)

Prenatal Plus Prescribing Information (FDA)

Prenatal Plus Iron Prescribing Information (FDA)

Prenate Elite tablets

Prenate Elite Prescribing Information (FDA)

Prenate Essential Prescribing Information (FDA)

PrimaCare ONE capsules

Renate DHA Prescribing Information (FDA)

Se-Natal 19 Prescribing Information (FDA)

Tandem DHA Prescribing Information (FDA)

Tandem OB Prescribing Information (FDA)

TriAdvance Prescribing Information (FDA)

Triveen-PRx RNF Prescribing Information (FDA)

UltimateCare ONE NF Prescribing Information (FDA)

Vinate AZ Prescribing Information (FDA)

Zatean-CH Prescribing Information (FDA)

Compare Neevo DHA with other medications

Vitamin/Mineral Supplementation during Pregnancy/Lactation

Friday, 5 October 2012

Buscopan Tablets

1. Name Of The Medicinal Product

Buscopan Tablets (POM)

Buscopan Cramps (P)

2. Qualitative And Quantitative Composition

Each tablet contains hyoscine butylbromide 10 mg.

3. Pharmaceutical Form

Coated tablets.

4. Clinical Particulars

4.1 Therapeutic Indications

Buscopan Tablets are indicated for the relief of spasm of the genito-urinary tract or gastro-intestinal tract and for the symptomatic relief of Irritable Bowel Syndrome.

4.2 Posology And Method Of Administration

Buscopan Tablets are for oral administration only.

Buscopan Tablets should be swallowed whole with adequate water.

Adults: 2 tablets four times daily. For the symptomatic relief of Irritable Bowel Syndrome, the recommended starting dose is 1 tablet three times daily, this can be increased up to 2 tablets four times daily if necessary.

Children 6 - 12 years: 1 tablet three times daily.

No specific information on the use of this product in the elderly is available. Clinical trials have included patients over 65 years and no adverse reactions specific to this age group have been reported.

4.3 Contraindications

Buscopan Tablets should not be administered to patients with myasthenia gravis, megacolon and narrow angle glaucoma. In addition, they should not be given to patients with a known hypersensitivity to hyoscine butylbromide or any other component of the product.

4.4 Special Warnings And Precautions For Use

Buscopan Tablets should be used with caution in conditions characterised by tachycardia such as thyrotoxicosis, cardiac insufficiency or failure and in cardiac surgery where it may further accelerate the heart rate. Due to the risk of anticholinergic complications, caution should be used in patients susceptible to intestinal or urinary outlet obstructions.

Because of the possibility that anticholinergics may reduce sweating, Buscopan should be administered with caution to patients with pyrexia.

Elevation of intraocular pressure may be produced by the administration of anticholinergic agents such as Buscopan in patients with undiagnosed and therefore untreated narrow angle glaucoma. Therefore, patients should seek urgent ophthalmological advice in case they should develop a painful, red eye with loss of vision whilst or after taking Buscopan.

As the tablet coat contains sucrose (41.2 mg), patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take Buscopan Tablets.

Additional warnings for the Patient Information Leaflet for the pharmacy only pack size (in relation to the Irritable Bowel Syndrome Indication)

Special warnings if you are taking Buscopan Tablets for Irritable Bowel Syndrome.

If this is the first time you have had symptoms of Irritable Bowel Syndrome, consult your doctor before using any treatment.

If any of the following apply to you do not take Buscopan Tablets. It may not be the right treatment for you. See your doctor as soon as possible.

• you are aged 40 years or over

• you have passed blood from the bowel

• you are feeling sick or vomiting

• you have lost your appetite or lost weight

• you are looking pale and feeling tired

• you are suffering from severe constipation

• you have a fever

• you have recently travelled abroad

• you have abnormal vaginal bleeding or discharge

• you have difficulty or pain passing urine

Consult your doctor if you have developed new symptoms, or if your symptoms worsen, or if they do not improve after 2 weeks of treatment.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

The anticholinergic effect of drugs such as tricyclic antidepressants, antihistamines, quinidine, amantadine, butyrophenones, phenothiazines, disopyramide and other anticholinergics (e.g. tiotropium, ipratropium) may be intensified by Buscopan.

Concomitant treatment with dopamine antagonists such as metoclopramide may result in diminution of the effects of both drugs on the gastrointestinal tract.

The tachycardic effects of beta-adrenergic agents may be enhanced by Buscopan.

4.6 Pregnancy And Lactation

Pregnancy

There are limited data from the use of hyoscine butylbromide in pregnant women. Animal studies are insufficient with respect to reproductive toxicity (see section 5.3). As a precautionary measure Buscopan is not recommended during pregnancy.

Lactation

There is insufficient information on the excretion of hyoscine butylbromide and its metabolites in human milk. A risk to the breastfeeding child cannot be excluded. Use of Buscopan during breastfeeding is not recommended.

Fertility

No studies on the effects on human fertility have been conducted.

4.7 Effects On Ability To Drive And Use Machines

No studies on the effects on the ability to drive and use machines have been performed. Because of possible visual accommodation disturbances patients should not drive or operate machinery if affected.

4.8 Undesirable Effects

Many of the undesirable effects can be assigned to the anticholinergic properties of BUSCOPAN.

Adverse events have been ranked under headings of frequency using the following convention:

Very common (

Immune system disorders

Rare: hypersensitivity

Not known: anaphylactic reactions with episodes of dyspnoea and anaphylactic shock

Uncommon: skin reactions

Cardiac disorders

Uncommon: tachycardia

Gastrointestinal disorders:

Uncommon: dry mouth

Skin and subcutaneous tissue disorders

Uncommon: dyshidrosis

Renal and urinary disorders

Rare: urinary retention

4.9 Overdose

Symptoms:

Serious signs of poisoning following acute overdosage have not been observed in man. In the case of overdosage, anticholinergic effects such as urinary retention, dry mouth, reddening of the skin, tachycardia, inhibition of gastrointestinal motility and transient visual disturbances may occur, and Cheynes-Stokes respiration has been reported.

Therapy:

In the case of oral poisoning, gastric lavage with medicinal charcoal should be followed by magnesium sulphate (15%). Symptoms of Buscopan overdosage respond to parasympathomimetics. For patients with glaucoma, pilocarpine should be given locally. Cardiovascular complications should be treated according to usual therapeutic principles. In case of respiratory paralysis, intubation and artificial respiration. Catheterisation may be required for urinary retention.

In addition, appropriate supportive measures should be administered as required.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Buscopan exerts a spasmolytic action on the smooth muscle of the gastrointestinal, biliary and genito-urinary tracts. As a quaternary ammonium derivative, hyoscine butylbromide does not enter the central nervous system. Therefore, anticholinergic side effects at the central nervous system do not occur. Peripheral anticholinergic action results from a ganglion-blocking action within the visceral wall as well as from an anti-muscarinic activity.

5.2 Pharmacokinetic Properties

Absorption

As a quaternary ammonium compound, hyoscine butylbromide is highly polar and hence only partially absorbed following oral (8%) or rectal (3%) administration. After oral administration of single doses of hyoscine butylbromide in the range of 20 to 400 mg, mean peak plasma concentrations between 0.11 ng/mL and 2.04 ng/mL were found at approximately 2 hours. In the same dose range, the observed mean AUC_0-tz-values varied from 0.37 to 10.7 ng h/mL. The median absolute bioavailabilities of different dosage forms, i.e. coated tablets, suppositories and oral solution, containing 100 mg of hyoscine butylbromide each were found to be less than 1%.

Distribution

Because of its high affinity for muscarinic receptors and nicotinic receptors, hyoscine butylbromide is mainly distributed on muscle cells of the abdominal and pelvic area as well as in the intramural ganglia of the abdominal organs. Plasma protein binding (albumin) of hyoscine butylbromide is approximately 4.4%. Animal studies demonstrate that hyoscine butylbromide does not pass the blood-brain barrier, but no clinical data to this effect is available. Hyoscine butylbromide (1 mM) has been observed to interact with the choline transport (1.4 nM) in epithelial cells of human placenta in vitro.

Metabolism and elimination

Following oral administration of single doses in the range of 100 to 400 mg, the terminal elimination half-lives ranged from 6.2 to 10.6 hours. The main metabolic pathway is the hydrolytic cleavage of the ester bond. Orally administered hyoscine butylbromide is excreted in the faeces and in the urine. Studies in man show that 2 to 5% of radioactive doses is eliminated renally after oral, and 0.7 to 1.6% after rectal administration. Approximately 90% of recovered radioactivity can be found in the faeces after oral administration. The urinary excretion of hyoscine butylbromide is less than 0.1% of the dose. The mean apparent oral clearances after oral doses of 100 to 400 mg range from 881 to 1420 L/min, whereas the corresponding volumes of distribution for the same range vary from 6.13 to 11.3 x 10⁵ L, probably due to very low systemic availability. The metabolites excreted via the renal route bind poorly to the muscarinic receptors and are therefore not considered to contribute to the effect of the hyoscine butylbromide.

5.3 Preclinical Safety Data

In limited reproductive toxicity studies hyoscine butylbromide showed no evidence of teratogenicity in rats at 200 mg/kg in the diet or in rabbits at 200 mg/kg by oral gavage or 50 mg/kg by subcutaneous injection. Fertility in the rat was not impaired at doses of up to 200 mg/kg in the diet.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Tablet core:

Calcium Hydrogen Phosphate

Maize Starch, Dried

Starch, Soluble

Colloidal Silica

Tartaric Acid

Stearic Acid

Tablet coating:

Sucrose

Talc

Acacia

Titanium Dioxide

Macrogol 6000

Carnauba Wax

White Beeswax

Povidone

6.2 Incompatibilities

None stated.

6.3 Shelf Life

Five years.

6.4 Special Precautions For Storage

Buscopan Tablets should be protected from light and stored in a dry place below 25°C.

6.5 Nature And Contents Of Container


Prescription Only status:	Blister packs of 56, 100, 500 and 560.
Pharmacy Only status:	Blister packs of 20 and 24.

Not all pack sizes may be marketed.

6.6 Special Precautions For Disposal And Other Handling

None stated.

7. Marketing Authorisation Holder

Boehringer Ingelheim Limited

Ellesfield Avenue

Bracknell

Berkshire

RG12 8YS

8. Marketing Authorisation Number(S)

PL 00015/0047R

9. Date Of First Authorisation/Renewal Of The Authorisation

13/9/2006

10. Date Of Revision Of The Text

February 2012

LEGAL CATEGORY


Buscopan Tablets	56, 100, 500 and 560 pack: POM
Buscopan Cramps	20 and 24 pack: P

Tuesday, 2 October 2012

Flagyl Oral, Intravenous

Generic Name: metronidazole (Oral route)

met-roe-NYE-da-zole

Oral route(Tablet;Tablet, Extended Release;Capsule)

Metronidazole has been shown to be carcinogenic in mice and rats. Unnecessary use of the drug should be avoided. Its use should be reserved only for conditions for which it is approved .

Commonly used brand name(s)

In the U.S.

Flagyl

Flagyl ER

Available Dosage Forms:

Tablet, Extended Release

Capsule

Tablet

Suspension

Therapeutic Class: Antibiotic

Chemical Class: Nitroimidazole

Uses For Flagyl

Metronidazole is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).

Metronidazole belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, metronidazole is used in certain patients with the following medical conditions:

Clostridium difficile diarrhea or colitis (antibiotic-associated colitis).

Crohn's disease (inflammatory bowel disease).

Gastritis or stomach ulcers due to Helicobacter pylori.

Giardiasis (parasite infection in the intestines).

Before Using Flagyl

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of metronidazole to treat bacterial infections in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of metronidazole in children with amebiasis.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of metronidazole in the elderly. However, elderly patients are more likely to have age-related liver problems, which may require caution and an adjustment in the dose for patients receiving metronidazole.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Amprenavir

Disulfiram

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amiodarone

Busulfan

Fluorouracil

Mycophenolate Mofetil

Warfarin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Carbamazepine

Cholestyramine

Cyclosporine

Lithium

Milk Thistle

Tacrolimus

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is not recommended. Your doctor may decide not to treat you with this medication, change some of the other medicines you take, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Proper Use of metronidazole

This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Flagyl. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

The regular tablet or capsule can be taken with or without food. If the medicine upsets your stomach, it is best to take it with a meal or snack.

The extended–release tablet must be taken without food, one hour before or two hours after a meal.

Swallow the extended-release tablet whole. Do not break, crush, or chew it.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop using this medicine too soon, your infection may return.

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times during the day. If you need help planning the best times to take your medicine, check with your doctor.

If you have taken a medicine called disulfiram (Antabuse®) within the last 2 weeks, do not take metronidazole until you talk to your doctor. Disulfiram is used to help people who have a drinking problem. If these 2 medicines are taken close together, serious unwanted effects may occur.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules or tablets):
- For amebiasis infections:
  - Adults and teenagers—500 or 750 milligrams (mg) 3 times per day for 5 to 10 days.
  - Children—Dose is based on body weight and must be determined by your doctor. The dose is usually 35 to 50 milligrams (mg) per kilogram (kg) of body weight per day, divided and given in 3 doses, for 10 days.
- For bacterial infections:
  - Adults and teenagers—Dose is based on body weight and must be determined by your doctor. The dose is usually 7.5 milligrams (mg) per kilogram (kg) of body weight, up to a maximum dose of 1 gram, every 6 hours for 7 to 10 days.
  - Children—Use and dose must be determined by your doctor.
- For trichomoniasis infections:
  - Adults and teenagers—The tablet can be given 3 different ways: as a single dose of 2 grams; or as 1 gram 2 times per day for 1 day; or as 250 milligrams (mg) 3 times per day for 7 days. The capsule dose is 375 mg 2 times per day for 7 days.
  - Children—Use and dose must be determined by your doctor.

For oral dosage form (extended-release tablets):
- For bacterial vaginosis:
  - Adults and teenagers—750 milligrams (mg) once a day for 7 days.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Flagyl

It is important that your doctor check your progress after you finish taking this medicine. This is to make sure that the infection is cleared up. Blood tests may be needed to check for unwanted effects.

If your symptoms do not improve within a few days after you start this medicine or if they become worse, check with your doctor.

Drinking alcoholic beverages while using this medicine may cause stomach pain, nausea, vomiting, headache, or flushing or redness of the face. Other alcohol-containing preparations (e.g., elixirs, cough syrups, tonics) may also cause problems. These problems may last for at least one day after you stop using metronidazole. This medicine may also cause alcoholic beverages to taste different. You should not drink alcoholic beverages or take other alcohol-containing preparations while you are using this medicine and for at least 3 days after stopping it.

Using this medicine while you are pregnant (especially during the first 3 months of pregnancy) can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

If you are using this medicine for trichomoniasis (an infection of the sex organs in men or women), your doctor may want to treat your sexual partner at the same time you are being treated, even if he or she has no symptoms. Also, it may be desirable to use a condom (rubber) during sexual intercourse. These measures will help to keep you from getting the infection back again from your partner. If you have any questions about this, check with your doctor.

Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.

Check with your doctor right away if you have dizziness, problems with muscle control or coordination, shakiness or an unsteady walk, slurred speech, or trouble with speaking. These may be symptoms of a serious brain condition called encephalopathy.

Call your doctor right away if you have confusion, drowsiness, fever, a general feeling of illness, a headache, loss of appetite, nausea, a stiff neck or back, or vomiting. These could be symptoms of a serious condition called aseptic meningitis.

Metronidazole may cause dry mouth, an unpleasant or sharp metallic taste, and a change in taste sensation. For temporary relief of dry mouth, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. If your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Flagyl Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Agitation

back pain

blindness

blurred vision

burning, numbness, tingling, or painful sensations in the hands or feet

changes in speech patterns

confusion

convulsions

decreased vision

depression

dizziness

drowsiness

eye pain

fever

hallucinations

headache

irritability

lack of coordination

mood or mental changes

nausea

seizures

shakiness and unsteady walk

slurred speech

stiff neck or back

trouble with speaking

unsteadiness, trembling, or other problems with muscle control or coordination

unusual tiredness or weakness

vomiting

weakness in the arms, hands, legs, or feet

Less common

Black, tarry stools

blood in the urine or stools

body aches or pain

chills

clumsiness or unsteadiness

difficulty with breathing

ear congestion

feeling of pelvic pressure

frequent or painful urination

loss of voice

nasal congestion

pinpoint red spots on the skin

runny nose

skin rash, hives, redness, or itching

sneezing

stomach and back pain (severe)

unusual bleeding or bruising

vaginal irritation, discharge, or dryness not present before taking the medicine

Rare

Bleeding gums

bloating

chest pain

constipation

cough

dark-colored urine

fast heartbeat

indigestion

loss of appetite

painful or difficult urination

pains in the stomach, side, or abdomen, possibly radiating to the back

shortness of breath

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swollen glands

yellow eyes or skin

Incidence not known

Blistering, peeling, or loosening of the skin

bloody or cloudy urine

burning while urinating

continuing diarrhea

continuing stomach pain

diarrhea

feeling of warmth

increased volume of pale, dilute urine

joint or muscle pain

loss of bladder control

red irritated eyes

red skin lesions, often with a purple center

redness of the face, neck, arms, and occasionally, upper chest

redness of the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abdominal or stomach cramps

dizziness or lightheadedness

feeling of constant movement of self or surroundings

heartburn

sensation of spinning

sleeplessness

trouble sleeping

unable to sleep

weight loss

Less common or rare

Change in taste sensation

congestion

dry mouth

pain or tenderness around the eyes and cheekbones

stuffy nose

tender, swollen glands in the neck

trouble with swallowing

unpleasant or sharp metallic taste

voice changes

Incidence not known

Decreased interest in sexual intercourse

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

painful sexual intercourse

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Flagyl Oral, Intravenous side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Flagyl Oral, Intravenous resources

Flagyl Oral, Intravenous Side Effects (in more detail)
Flagyl Oral, Intravenous Use in Pregnancy & Breastfeeding
Drug Images
Flagyl Oral, Intravenous Drug Interactions
Flagyl Oral, Intravenous Support Group
31 Reviews for Flagyl Oral, Intravenous - Add your own review/rating

Compare Flagyl Oral, Intravenous with other medications

Amebiasis
Aspiration Pneumonia
Bacteremia
Bacterial Infection
Bone infection
Clostridial Infection
Crohn's Disease, Acute
Crohn's Disease, Maintenance
Deep Neck Infection
Dental Abscess
Diverticulitis
Dracunculiasis
Endocarditis
Giardiasis
Helicobacter Pylori Infection
Intraabdominal Infection
Joint Infection
Meningitis
Pelvic Inflammatory Disease
Peritonitis
Pneumonia
Pseudomembranous Colitis
Skin Infection
Surgical Prophylaxis
Trichomoniasis

Monday, 1 October 2012

Gen-K Powder

Pronunciation: po-TAS-ee-um KLOR-ide
Generic Name: Potassium Chloride
Brand Name: Examples include Gen-K and Klor-con

Gen-K Powder is used for:

Preventing or treating low blood potassium levels when the amount of potassium in the diet is inadequate. Low potassium levels may also be caused by some diseases, severe or prolonged episodes of vomiting or diarrhea, or by certain medicines (eg, diuretics). Symptoms of low potassium levels include weakness, fatigue, or weakening of reflexes.

Gen-K Powder is an electrolyte that is needed for normal functioning of cells, nerve conduction, muscle contraction, kidney function, and acid-base balance.

Do NOT use Gen-K Powder if:

you are allergic to any ingredient in Gen-K Powder

you have a high blood potassium level

you are taking a potassium-sparing diuretic (eg, triamterene)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Gen-K Powder:

Some medical conditions may interact with Gen-K Powder. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a high acidity of your body fluids (acidosis), adrenal gland problems, diarrhea, or kidney problems

Some MEDICINES MAY INTERACT with Gen-K Powder. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aldosterone blockers (eg, spironolactone), angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or potassium-sparing diuretics (eg, triamterene) because the risk of high blood potassium levels may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Gen-K Powder may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Gen-K Powder:

Use Gen-K Powder as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Gen-K Powder may cause stomach upset. Take Gen-K Powder by mouth with food or after meals.

Dissolve Gen-K Powder in at least half a glass (4 oz/120 mL) of water or juice and drink.

Do not lie down for 30 minutes after taking Gen-K Powder.

If you miss a dose of Gen-K Powder, take it if you remember within 2 hours. If it is more than 2 hours since your missed dose, skip it and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Gen-K Powder.

Important safety information:

Check with your doctor before you use a salt substitute or a product that has potassium in it.

Too much or too little potassium can adversely affect your heart. Be sure that your health care provider and pharmacist are aware of any heart medications that you are taking.

Lab tests, including blood electrolytes and kidney function, may be performed while you use Gen-K Powder. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Gen-K Powder with caution in the ELDERLY; they may be more sensitive to its effects.

Gen-K Powder should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Gen-K Powder while you are pregnant. It is not known if Gen-K Powder is found in breast milk. If you are or will be breast-feeding while you use Gen-K Powder, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Gen-K Powder:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; nausea; stomach discomfort; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; bleeding in the stomach; chest pain; heart problems; irregular heartbeat; numbness or tingling in the hands or feet; stomach pain; vomit that looks like coffee grounds; weak or heavy legs.

See also: Gen-K side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; fast, slow, or irregular heartbeat; limp muscles; listlessness; muscle weakness or paralysis; slow or difficult breathing.

Proper storage of Gen-K Powder:

Store Gen-K Powder at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Gen-K Powder out of the reach of children and away from pets.

General information:

If you have any questions about Gen-K Powder, please talk with your doctor, pharmacist, or other health care provider.

Gen-K Powder is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Gen-K Powder. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Gen-K resources

Gen-K Side Effects (in more detail)
Gen-K Use in Pregnancy & Breastfeeding
Gen-K Drug Interactions
Gen-K Support Group
0 Reviews for Gen-K - Add your own review/rating

Compare Gen-K with other medications

Hypokalemia
Prevention of Hypokalemia

Saturday, 29 September 2012

chlorpheniramine, hydrocodone, and pseudoephedrine

Generic Name: chlorpheniramine, hydrocodone, and pseudoephedrine (KLOR fe NEER a meen, HYE droe KOE done, SOO doe ee FED rin)

Brand names: Cordron-HC, Cordron-HC NR, Detuss, Hydrocof-HC, Hydron PCS, Hyphed, JayCof-HC, Notuss-Forte, P-V-Tussin Syrup, Q-V Tussin, Welltuss HC, Zutripro, ...show all 24 brand names.

What is chlorpheniramine, hydrocodone, and pseudoephedrine?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Hydrocodone is a narcotic cough medicine.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine, hydrocodone, and pseudoephedrine is used to treat runny or stuffy nose, sinus congestion, and cough caused by the common cold or flu.

Chlorpheniramine, hydrocodone, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about chlorpheniramine, hydrocodone, and pseudoephedrine?

Do not take this medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use chlorpheniramine, hydrocodone, and pseudoephedrine before the MAO inhibitor has cleared from your body. Chlorpheniramine, hydrocodone, and pseudoephedrine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine, hydrocodone, and pseudoephedrine. Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine, hydrocodone, and pseudoephedrine. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Never share hydrocodone with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

What should I discuss with my healthcare provider before taking chlorpheniramine, hydrocodone, and pseudoephedrine?

To make sure you can safely take this medication, tell your doctor if you have any of these other conditions:

asthma, COPD, sleep apnea, or other breathing disorder;

liver or kidney disease;

heart disease or high blood pressure;

diabetes;

a thyroid disorder;

curvature of the spine;

a history of head injury or brain tumor;

epilepsy or other seizure disorder;

low blood pressure;

glaucoma;

gallbladder disease;

Addison's disease or other adrenal gland disorders;

enlarged prostate, urination problems;

mental illness; or

a history of drug or alcohol addiction.

Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Never share hydrocodone with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. FDA pregnancy category C. It is not known whether chlorpheniramine, hydrocodone, and pseudoephedrine will harm an unborn baby. Hydrocodone may cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using chlorpheniramine, hydrocodone, and pseudoephedrine. It is not known whether chlorpheniramine, hydrocodone, and pseudoephedrine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take chlorpheniramine, hydrocodone, and pseudoephedrine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

You may take this medication with or without food.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Store at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Hydrocodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

See also: Chlorpheniramine, hydrocodone, and pseudoephedrine dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of hydrocodone can be fatal.

Overdose symptoms may include extreme drowsiness, feeling restless or nervous, vomiting, stomach pain, warmth or tingly feeling, seizure (convulsions), pinpoint pupils, confusion, cold and clammy skin, weak pulse, shallow breathing, fainting, or breathing that stops.

What should I avoid while taking chlorpheniramine, hydrocodone, and pseudoephedrine?

Chlorpheniramine, hydrocodone, and pseudoephedrine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine, hydrocodone, and pseudoephedrine.

Chlorpheniramine, hydrocodone, and pseudoephedrine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

severe dizziness, anxiety, restless feeling, or nervousness;

fast, pounding, or uneven heartbeats;

shallow breathing, slow heartbeat;

confusion, hallucinations, unusual thoughts or behavior;

feeling like you might pass out;

urinating less than usual or not at all;

easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, chest pain, shortness of breath, seizure); or

upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

nausea, vomiting, upset stomach, constipation;

dry mouth;

blurred vision;

dizziness, drowsiness;

problems with memory or concentration;

sleep problems (insomnia);

ringing in your ears;

warmth, tingling, or redness under your skin; or

skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Chlorpheniramine, hydrocodone, and pseudoephedrine Dosing Information

Usual Adult Dose for Cough and Nasal Congestion:

Chlorpheniramine/hydrocodone/pseudoephedrine 2 mg-5 mg-30 mg oral capsule:
1 to 2 capsules orally every 8 hours.

Chlorpheniramine/hydrocodone/pseudoephedrine 2.5 mg-1.67 mg-17.5 mg/5 mL oral liquid:
10 mL orally every 4 to 6 hours not to exceed 40 mL daily.

Chlorpheniramine/hydrocodone/pseudoephedrine 2.5 mg-1.67 mg-20 mg/5 mL oral liquid:
10 mL orally every 4 to 6 hours.

Chlorpheniramine/hydrocodone/pseudoephedrine 4 mg-5 mg-30 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours.

Chlorpheniramine/hydrocodone/pseudoephedrine 4 mg-5 mg-40 mg/5 mL oral syrup:
5 mL orally 3 to 4 times daily not to exceed 4 doses per day.

Chlorpheniramine/hydrocodone/pseudoephedrine 4 mg-5 mg-60 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours not to exceed 4 doses per day.

Usual Pediatric Dose for Cough and Nasal Congestion:

Chlorpheniramine/hydrocodone/pseudoephedrine 2 mg-5 mg-30 mg oral capsule:
6 to 11 years: 1 capsule orally every 8 hours.
12 years or older: 1 to 2 capsules orally every 8 hours.

Chlorpheniramine/hydrocodone/pseudoephedrine 2.5 mg-1.67 mg-17.5 mg/5 mL oral liquid:
2 to 5 years: 2.5 mL orally every 4 to 6 hours not to exceed 10 mL daily.
6 to 11 years: 5 mL orally every 4 to 6 hours not to exceed 20 mL daily.
12 years or older: 10 mL orally every 4 to 6 hours not to exceed 40 mL daily.

Chlorpheniramine/hydrocodone/pseudoephedrine 2.5 mg-1.67 mg-20 mg/5 mL oral liquid:
2 to 5 years: 2.5 mL orally every 4 to 6 hours.
6 to 11 years: 5 mL orally every 4 to 6 hours.
12 years or older: 10 mL orally every 4 to 6 hours.

Chlorpheniramine/hydrocodone/pseudoephedrine 4 mg-5 mg-30 mg/5 mL oral suspension, extended release:
2 to 5 years: 2.5 mL orally every 12 hours.
6 to 11 years: 2.5 to 5 mL orally every 12 hours.
12 years or older: 5 to 10 mL orally every 12 hours.

Chlorpheniramine/hydrocodone/pseudoephedrine 4 mg-5 mg-40 mg/5 mL oral syrup:
6 to 11 years: 2.5 mL orally 3 to 4 times daily not to exceed 4 doses per day.
12 years or older: 5 mL orally 3 to 4 times daily not to exceed 4 doses per day.

What other drugs will affect chlorpheniramine, hydrocodone, and pseudoephedrine?

Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine, hydrocodone, and pseudoephedrine.

Tell your doctor about all other medications you use, especially:

blood pressure medication;

cimetidine (Tagamet);

rifampin (Rifadin, Rifater, Rifamate, Rimactane);

zidovudine (Retrovir, AZT);

an antidepressant;

a diuretic (water pill);

medication to treat irritable bowel syndrome;

bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);

aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

seizure medication such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton);

a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others; or

medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril).

This list is not complete and other drugs may interact with chlorpheniramine, hydrocodone, and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More chlorpheniramine, hydrocodone, and pseudoephedrine resources

Chlorpheniramine, hydrocodone, and pseudoephedrine Side Effects (in more detail)
Chlorpheniramine, hydrocodone, and pseudoephedrine Dosage
Chlorpheniramine, hydrocodone, and pseudoephedrine Use in Pregnancy & Breastfeeding
Chlorpheniramine, hydrocodone, and pseudoephedrine Drug Interactions
Chlorpheniramine, hydrocodone, and pseudoephedrine Support Group
4 Reviews for Chlorpheniramine, hydrocodone, and pseudoephedrine - Add your own review/rating

Compare chlorpheniramine, hydrocodone, and pseudoephedrine with other medications

Cough and Nasal Congestion

Where can I get more information?

Your pharmacist can provide more information about chlorpheniramine, hydrocodone, and pseudoephedrine.

See also: chlorpheniramine, hydrocodone, and pseudoephedrine side effects (in more detail)

Pediatex-CT Chewable Tablets

Pronunciation: dye-fen-HYE-dra-meen/fen-ill-EF-rin
Generic Name: Diphenhydramine/Phenylephrine
Brand Name: Examples include D-Tann and Pediatex-CT

Pediatex-CT Chewable Tablets are used for:

Temporarily relieving symptoms of hay fever, allergies, or the common cold, including nasal congestion, runny nose, sneezing, itching of the nose and throat, and itchy/watery eyes. It may also be used for other conditions as determined by your doctor.

Pediatex-CT Chewable Tablets are an antihistamine and decongestant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The decongestant promotes sinus and nasal drainage, relieving congestion and pressure.

Do NOT use Pediatex-CT Chewable Tablets if:

you are allergic to any ingredient in Pediatex-CT Chewable Tablets

you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the past 14 days

you have severe high blood pressure, severe heart blood vessel disease, a rapid heartbeat, or severe heart problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pediatex-CT Chewable Tablets:

Some medical conditions may interact with Pediatex-CT Chewable Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a fast, slow, or irregular heartbeat

if you have a history of glaucoma; high blood pressure; diabetes; heart problems; ulcers; stroke; asthma; an overactive thyroid; seizures; a blockage of the stomach, bowel, or bladder; trouble breathing when you sleep; trouble sleeping; lung problems (eg, emphysema); the blood disease porphyria; or an enlarged prostate or other prostate problems; adrenal gland problems; blood vessel problems; or if you have difficulty urinating

Some MEDICINES MAY INTERACT with Pediatex-CT Chewable Tablets. Tell your health care provider if you are taking any other medicines, especially if any of the following apply to you:

Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), indomethacin, furazolidone, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because side effects such as severe headache, high blood pressure, or high fever may occur

Bromocriptine or sodium oxybate (GHB) because the risk of side effects or toxic effects may be increased by Pediatex-CT Chewable Tablets

Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Pediatex-CT Chewable Tablets.

Digoxin or droxidopa because side effects such as irregular heartbeat or heart attack may occur

Urinary alkalinizers (eg, sodium bicarbonate) because the side effects of Pediatex-CT Chewable Tablets may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pediatex-CT Chewable Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pediatex-CT Chewable Tablets:

Use Pediatex-CT Chewable Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Pediatex-CT Chewable Tablets may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Chew thoroughly before swallowing.

If you miss a dose of Pediatex-CT Chewable Tablets and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pediatex-CT Chewable Tablets.

Important safety information:

Pediatex-CT Chewable Tablets may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Pediatex-CT Chewable Tablets. Using Pediatex-CT Chewable Tablets alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Pediatex-CT Chewable Tablets. Pediatex-CT Chewable Tablets will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.

Contact your health care provider if symptoms last for more than 7 days or are accompanied by a fever.

Diabetes patients - Pediatex-CT Chewable Tablets may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

Pediatex-CT Chewable Tablets contains phenylephrine and diphenhydramine. Before you begin taking any new prescription or nonprescription medicine, including medicine used on the skin, read the ingredients to see if it also contains phenylephrine or diphenhydramine. If it does, or if you are uncertain if it does, contact your doctor or pharmacist.

If you are scheduled for allergy skin testing, do not take Pediatex-CT Chewable Tablets for several days before the test because it may decrease your response to the skin tests.

Do not take diet or appetite control medicines while you are taking Pediatex-CT Chewable Tablets without checking with your doctor.

Do not exceed the recommended dose or take Pediatex-CT Chewable Tablets for longer than prescribed without checking with your doctor.

If you have trouble sleeping, ask your pharmacist or doctor about the best time of day to take Pediatex-CT Chewable Tablets.

Use Pediatex-CT Chewable Tablets with caution in the ELDERLY because they may be more sensitive to its effects.

Pediatex-CT Chewable Tablets are not recommended for use in NEWBORNS. Safety and effectiveness have not been confirmed.

Different products may have different dosing instructions for CHILDREN on the package labeling. Follow the dosing instructions provided on the package labeling or by your doctor. If you are unsure of what dose to give a child, check with your doctor.

Caution is advised when using Pediatex-CT Chewable Tablets in CHILDREN because they may be more sensitive to its effects, especially excitability.

PREGNANCY AND BREAST-FEEDING: If you become pregnant while taking Pediatex-CT Chewable Tablets, discuss with your doctor the benefits and risks of using Pediatex-CT Chewable Tablets during pregnancy. If you are or will be breast-feeding while you are using Pediatex-CT Chewable Tablets, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Pediatex-CT Chewable Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability (especially in children); headache; loss of appetite; nausea; nervousness; restlessness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; decreased coordination; difficulty urinating; fast or irregular heartbeat; fever; hallucinations; seizure; severe dizziness and drowsiness; severe nervousness, anxiety, or restlessness; tremors; unusual weakness.

See also: Pediatex-CT side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include bluish-colored skin; difficulty breathing; dilated pupils; fast or irregular heartbeat; fever; flushing; hallucinations; mental or mood changes; seizures; severe drowsiness or dizziness; severe excitability; severe nausea or vomiting; sweating; tremors.

Proper storage of Pediatex-CT Chewable Tablets:

Store Pediatex-CT Chewable Tablets at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pediatex-CT Chewable Tablets out of the reach of children and away from pets.

General information:

If you have any questions about Pediatex-CT Chewable Tablets, please talk with your doctor, pharmacist, or other health care provider.

Pediatex-CT Chewable Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Pediatex-CT Chewable Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Pediatex-CT resources

Pediatex-CT Side Effects (in more detail)
Pediatex-CT Use in Pregnancy & Breastfeeding
Pediatex-CT Drug Interactions
Pediatex-CT Support Group
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